Gut Bacteria – Their Role in Depression

by David Perlmutter, M.D., Board-Certified Neurologist, #1 New York Times Best-Selling Author, Fellow of the American College of Nutrition

December of 2019 marked the publication of a new medical textbook entitled, The Microbiome and the Brain (CRC Press).  The text features chapters focused on a number of important topics including the role of the gut bacteria in a variety of medical conditions including autism, multiple sclerosis and Alzheimer’s disease. The common theme throughout the book, as one would surmise from the title, is the relationship between the gut and brain health. The chapters have been written by some of the most well respected researchers and clinicians from around the world, and I am honored to be the editor-in-chief of this important contribution.

One area in which the relationship between the gut and the brain that seems to be getting a lot of attention as of late focuses on how variations in the gut bacteria may ultimately contribute to alterations in mood. Specifically, there is currently a fairly in depth pursuit to understand the relationship between nuances of bacterial constituents and depression.

In a recent publications entitled, The neuroactive potential of the human gut microbiota in quality of life and depression published in the journal, Nature Microbiology, researchers in Belgium surveyed the gut microbiome in 1,054 individuals and set about correlating their findings with measurements of both quality of life indicators as well as depression status in the participants.

The correlations revealed by the study are quite interesting. The researchers found, for example, that lower levels of a specific organism, Bacteriodes enterotype 2, displayed lower measurements of quality of life as well as higher prevalence of depression. Higher quality of life indicators were consistently correlated with higher levels of two types of organisms, Faecalibacterium and Coprococcus. Interestingly, these are organisms that are known produce the short chain fatty acid butyrate and are known to be associated with reduced inflammation as well.

The researchers then went further and evaluated the genetics that underlie how specific organisms manufacture neurochemicals that are suspected of playing a role in regulating mood in humans. Their results were fascinating. Correlations between these pathways, including those involved in the neurotransmitters dopamine and GABA were described.

While we don’t yet have the ability to draw conclusions regarding the role of specific bacteria in regulating mood, these findings indicate that we are at least on the trail. One important takeaway is the relationship between lower levels of bacteria that reduce inflammation and depression as we now recognize that depression is fundamentally an inflammatory disorder. What is actionable in all of this is that our food choices are highly influential in terms of modulating the complexion of our gut bacteria and as such, offer us a tool that may have important implications as it relates to things like depression. You’ll learn more about the specifics of food and depression in a recent blog  by Austin Perlmutter, MD.
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